UNOFFICIAL COPY 25 RS BR 2025 Page 1 of 2 XXXX 3/12/2025 7:15 PM Jacketed A RESOLUTION encouraging the Kentucky Department for Public Health, in 1 conjunction with the Kentucky Office of Drug Control Policy, to issue a public statement 2 to increase awareness in the Commonwealth on the potential harm of consuming 7-3 hydroxymitragynine products. 4 WHEREAS, kratom contains two main chemical compounds, mitragynine and 7-5 hydroyxmitragynine, both of which bind to the same receptors in the brain as opioid 6 drugs such as codeine; and 7 WHEREAS, mitragynine is naturally present in kratom in much higher quantities 8 than 7-hydroxymitragynine; and 9 WHEREAS, 7-hydroxymitragynine is a terpenoid indole alkaloid that acts on the 10 brain’s opioid receptors; and 11 WHEREAS, according to the United States Food and Drug Administration, 7-12 hydroxymitragynine may produce classic opioid-related effects including sedation, 13 nausea and vomiting, physical dependence and withdrawals, and respiratory depression; 14 and 15 WHEREAS, 7-hydroxymitragynine is an addictive substance; and 16 WHEREAS, food chemists have developed techniques to synthesize 7-17 hydroxymitragynine from mitragynine allowing the artificial increase in the levels of 7-18 hydroxymitragynine in kratom products; and 19 WHEREAS, according to a study published in the Addiction Biology Journal, the 20 consumption of 7-hydroxymitragynine can lead to an increased utilization of other 21 opioids including morphine; and 22 WHEREAS, the analgesic properties of 7-hydroxymitragynine are 13 times greater 23 than morphine; and 24 WHEREAS, there are companies marketing products labeled as kratom that may 25 primarily contain the more potent synthetic product called 7-hydroxmitragynine; 26 NOW, THEREFORE, 27 UNOFFICIAL COPY 25 RS BR 2025 Page 2 of 2 XXXX 3/12/2025 7:15 PM Jacketed Be it resolved by the House of Representatives of the General Assembly of the 1 Commonwealth of Kentucky: 2 Section 1. The members of the House of Representatives encourage the 3 Kentucky Department for Public Health, in conjunction with the Kentucky Office of 4 Drug Control Policy, to issue a public statement to increase awareness in the 5 Commonwealth on the potential harm of consuming 7-hydroxymitragynine products. 6 Section 2. The Clerk of the House of Representatives is directed to transmit a 7 copy of this Resolution to the Kentucky Department for Public Health, the Kentucky 8 Office of Drug Control Policy, and the Governor. 9