MISSISSIPPI LEGISLATURE 2025 Regular Session To: Drug Policy By: Senator(s) Hill Senate Bill 2224 AN ACT TO AMEND SECTION 41-29-119, MISSISSIPPI CODE OF 1972, TO ADD MIFEPRISTONE AND MISOPROSTOL TO SCHEDULE IV OF THE UNIFORM CONTROLLED SUBSTANCES ACT; AND FOR RELATED PURPOSES. BE IT ENACTED BY THE LEGISLATURE OF THE STATE OF MISSISSIPPI: SECTION 1. Section 41-29-119, Mississippi Code of 1972, is amended as follows: 41-29-119. (A) The controlled substances listed in this section are included in Schedule IV. SCHEDULE IV (a) Narcotic drugs. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture or preparation which contains limited quantities of the following narcotic drugs, or any salts thereof: (1) Not more than one (1) milligram of difenoxin and not less than twenty-five (25) micrograms of atropine sulfate per dosage unit; (2) Dextropropoxyphene, including its salts (Darvon, Darvon-N; also found in Darvon compound and Darvocet-N, etc.); (3) 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol, its salts, optical and geometric isomers and salts of these isomers (including tramadol). (b) Depressants. Any material, compound, mixture or preparation which contains any quantity of the following substances: (1) Alfaxalone; (2) Alprazolam; (3) Barbital; (4) Brexanolone; (5) Bromazepam; (6) Camazepam; (7) Carisoprodol; (8) Chloral betaine; (9) Chloral hydrate; (10) Chlordiazepoxide and its salts, but does not include chlordiazepoxide hydrochloride and clidinium bromide or chlordiazepoxide and esterified estrogens; (11) Clobazam; (12) Clonazepam; (13) Clorazepate; (14) Clotiazepam; (15) Cloxazolam; (16) Daridorexant ([(S)-2-(5-chloro-4-methyl-1H-benzo[d]imidazol-2-yl)-2- methylpyrrolidin-1-yl](5-methoxy-2-(2H-1,2,3-triazol-2- yl)phenyl)methanone), including its salts, isomers, and salts of isomers; (17) Delorazepam; (18) Diazepam; (19) Dichloralphenazone; (20) Estazolam; (21) Ethchlorvynol; (22) Ethinamate; (23) Ethyl loflazepate; (24) Fludiazepam; (25) Flunitrazepam; (26) Flurazepam; (27) Fospropofol; (28) Halazepam; (29) Haloxazolam; (30) Ketazolam; (31) Lemborexant; (32) Loprazolam; (33) Lorazepam; (34) Lormetazepam; (35) Mebutamate; (36) Medazepam; (37) Meprobamate; (38) Methohexital; (39) Methylphenobarbital; (40) Midazolam; (41) Nimetazepam; (42) Nitrazepam; (43) Nordiazepam; (44) Oxazepam; (45) Oxazolam; (46) Paraldehyde; (47) Petrichloral; (48) Phenobarbital; (49) Pinazepam; (50) Prazepam; (51) Quazepam; (52) Remimazolam; (53) Suvorexant; (54) Temazepam; (55) Tetrazepam; (56) Triazolam; (57) Zaleplon; (58) Zolpidem; (59) Zopiclone. (c) [Deleted] (d) Lorcaserin. Any material, compound, mixture, or preparation which contains any quantity of Lorcaserin, including its salts, isomers, and salts of such isomers, whenever the existence of such salts, isomers, and salts of isomers is possible. (e) Stimulants. Any material, compound, mixture or preparation which contains any quantity of the following substances: (1) Cathine ((+/-) Norpseudoephedrine); (2) Diethylpropion; (3) Fencamfamin; (4) Fenproporex; (5) Mazindol; (6) Mefenorex; (7) Modafinil; (8) Pemoline (including any organometallic complexes and chelates thereof); (9) Phentermine; (10) Pipradrol; (11) Serdexmethylphenidate; (12) Sibutramine; (13) Solriamfetol; (14) SPA ((-)-1-dimethylamino-1,2-diphenylethane). (f) Other substances. (1) Pentazocine; (2) Butorphanol (including its optical isomers); (3) Eluxadoline (5-[[[(2S)-2-amino-3-[4-aminocarbonyl)-2,6-dimethylphenyl]-1-oxopropyl][(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino]methyl]-2-methoxybenzoic acid); (including its optical isomers) and its salts, isomers, and salts of isomers; (4) Zuranolone and its salts, isomers, and salts of isomers * * *.; (5) Mifepristone, Misoprostol. Unless listed in another schedule, any material, compound, mixture, or preparation containing any detectable quantity of mifepristone or misoprostol. (B) Any material, compound, mixture or preparation which contains any quantity of a Schedule IV controlled substance and is listed as an exempt substance in 21 CFR, Section 1308.22, 1308.24, 1308.26, 1308.32 or 1308.34, shall be exempted from the provisions of the Uniform Controlled Substances Law. SECTION 2. This act shall take effect and be in force from and after July 1, 2025.
MISSISSIPPI LEGISLATURE
2025 Regular Session
To: Drug Policy
By: Senator(s) Hill
# Senate Bill 2224
AN ACT TO AMEND SECTION 41-29-119, MISSISSIPPI CODE OF 1972, TO ADD MIFEPRISTONE AND MISOPROSTOL TO SCHEDULE IV OF THE UNIFORM CONTROLLED SUBSTANCES ACT; AND FOR RELATED PURPOSES.
BE IT ENACTED BY THE LEGISLATURE OF THE STATE OF MISSISSIPPI:
SECTION 1. Section 41-29-119, Mississippi Code of 1972, is amended as follows:
41-29-119. (A) The controlled substances listed in this section are included in Schedule IV.
SCHEDULE IV
(a) Narcotic drugs. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture or preparation which contains limited quantities of the following narcotic drugs, or any salts thereof:
(1) Not more than one (1) milligram of difenoxin and not less than twenty-five (25) micrograms of atropine sulfate per dosage unit;
(2) Dextropropoxyphene, including its salts (Darvon, Darvon-N; also found in Darvon compound and Darvocet-N, etc.);
(3) 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol, its salts, optical and geometric isomers and salts of these isomers (including tramadol).
(b) Depressants. Any material, compound, mixture or preparation which contains any quantity of the following substances:
(1) Alfaxalone;
(2) Alprazolam;
(3) Barbital;
(4) Brexanolone;
(5) Bromazepam;
(6) Camazepam;
(7) Carisoprodol;
(8) Chloral betaine;
(9) Chloral hydrate;
(10) Chlordiazepoxide and its salts, but does not include chlordiazepoxide hydrochloride and clidinium bromide or chlordiazepoxide and esterified estrogens;
(11) Clobazam;
(12) Clonazepam;
(13) Clorazepate;
(14) Clotiazepam;
(15) Cloxazolam;
(16) Daridorexant
([(S)-2-(5-chloro-4-methyl-1H-benzo[d]imidazol-2-yl)-2-
methylpyrrolidin-1-yl](5-methoxy-2-(2H-1,2,3-triazol-2-
yl)phenyl)methanone), including its salts, isomers, and salts of isomers;
(17) Delorazepam;
(18) Diazepam;
(19) Dichloralphenazone;
(20) Estazolam;
(21) Ethchlorvynol;
(22) Ethinamate;
(23) Ethyl loflazepate;
(24) Fludiazepam;
(25) Flunitrazepam;
(26) Flurazepam;
(27) Fospropofol;
(28) Halazepam;
(29) Haloxazolam;
(30) Ketazolam;
(31) Lemborexant;
(32) Loprazolam;
(33) Lorazepam;
(34) Lormetazepam;
(35) Mebutamate;
(36) Medazepam;
(37) Meprobamate;
(38) Methohexital;
(39) Methylphenobarbital;
(40) Midazolam;
(41) Nimetazepam;
(42) Nitrazepam;
(43) Nordiazepam;
(44) Oxazepam;
(45) Oxazolam;
(46) Paraldehyde;
(47) Petrichloral;
(48) Phenobarbital;
(49) Pinazepam;
(50) Prazepam;
(51) Quazepam;
(52) Remimazolam;
(53) Suvorexant;
(54) Temazepam;
(55) Tetrazepam;
(56) Triazolam;
(57) Zaleplon;
(58) Zolpidem;
(59) Zopiclone.
(c) [Deleted]
(d) Lorcaserin. Any material, compound, mixture, or preparation which contains any quantity of Lorcaserin, including its salts, isomers, and salts of such isomers, whenever the existence of such salts, isomers, and salts of isomers is possible.
(e) Stimulants. Any material, compound, mixture or preparation which contains any quantity of the following substances:
(1) Cathine ((+/-) Norpseudoephedrine);
(2) Diethylpropion;
(3) Fencamfamin;
(4) Fenproporex;
(5) Mazindol;
(6) Mefenorex;
(7) Modafinil;
(8) Pemoline (including any organometallic complexes and chelates thereof);
(9) Phentermine;
(10) Pipradrol;
(11) Serdexmethylphenidate;
(12) Sibutramine;
(13) Solriamfetol;
(14) SPA ((-)-1-dimethylamino-1,2-diphenylethane).
(f) Other substances.
(1) Pentazocine;
(2) Butorphanol (including its optical isomers);
(3) Eluxadoline (5-[[[(2S)-2-amino-3-[4-aminocarbonyl)-2,6-dimethylphenyl]-1-oxopropyl][(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino]methyl]-2-methoxybenzoic acid); (including its optical isomers) and its salts, isomers, and salts of isomers;
(4) Zuranolone and its salts, isomers, and salts of isomers * * *.;
(5) Mifepristone, Misoprostol. Unless listed in another schedule, any material, compound, mixture, or preparation containing any detectable quantity of mifepristone or misoprostol.
(B) Any material, compound, mixture or preparation which contains any quantity of a Schedule IV controlled substance and is listed as an exempt substance in 21 CFR, Section 1308.22, 1308.24, 1308.26, 1308.32 or 1308.34, shall be exempted from the provisions of the Uniform Controlled Substances Law.
SECTION 2. This act shall take effect and be in force from and after July 1, 2025.