North Carolina 2025-2026 Regular Session

North Carolina House Bill H330 Compare Versions

Version 1 (Old)

Version 2 (New)

Old	New		Differences
1	1		GENERAL ASSEMBLY OF NORTH CAROLINA
2	2		SESSION 2025
3		-	H 2
	3	+	H 1
4	4		HOUSE BILL 330
5		-	~~Committee Substitute Favorable 3/18/25~~
	5	+
6	6
7	7		Short Title: Controlled Substances Act - Updates. (Public)
8		-	Sponsors:
9		-	Referred to:
	8	+	Sponsors: Representatives Huneycutt, Miller, Pyrtle, and Rhyne (Primary Sponsors).
	9	+	For a complete list of sponsors, refer to the North Carolina General Assembly web site.
	10	+	Referred to: Judiciary 2, if favorable, Rules, Calendar, and Operations of the House
10	11		March 10, 2025
11		-	H330 -v-2
	12	+	H330 -v-1
12	13		A BILL TO BE ENTITLED 1
13	14		AN ACT TO UPDATE THE CONTROLLED SUBSTANC ES ACT. 2
14	15		The General Assembly of North Carolina enacts: 3
15	16		SECTION 1.(a) G.S. 90-89(1) reads as rewritten: 4
16	17		"(1) Opiates. – Any of the following opiates or opioids, including the isomers, 5
17	18		esters, ethers, salts and salts of isomers, esters, and ethers, unless specifically 6
18	19		excepted, or listed in another schedule, whenever the existence of such 7
19	20		isomers, esters, ethers, and salts is possible within the specific chemical 8
20	21		designation: 9
21	22		… 10
22	23		sss. AP-237. 11
23	24		ttt. 2-methyl AP-237. 12
24	25		uuu. (ortho, meta, or para)-methyl AP-237. 13
25	26		vvv. AP-238. 14
26	27		www. (ortho, meta, or para)-hydroxy 2-methyl AP-237. 15
27	28		xxx. 2-Naphthyl U-47700. 16
28	29		yyy. 1-Naphthyl U-47700. 17
29	30		zzz. 4-(Trifluoromethyl) U-47700. 18
30	31		aaaa. Methoxy U-47700. 19
31	32		bbbb. Furanyl UF-17. 20
32	33		cccc. Cyclopropyl U-47700. 21
33	34		dddd. Phenyl U-47700. 22
34	35		eeee. Ethyl U-47700. 23
35	36		ffff. (2,3- or 3,4)-difluoro-N,N-didesmethyl U-47700. 24
36	37		gggg. (2,3- or 3,4)-difluoro U-49900. 25
37	38		hhhh. (2,3- or 3,4)-difluoro-N-desmethyl U-47700. 26
38	39		iiii. 4-fluoro U-47931E. 27
39	40		jjjj. (2,3- or 3,4)-difluoro U-51754. 28
40	41		kkkk. (2,3- or 3,4)-difluoro Isopropyl U-47700. 29
41	42		llll. (2,3- or 3,4)-difluoro Propyl U-47700. 30
42	43		mmmm. (2,3- or 3,4)-difluoro U-50488. 31
43	44		nnnn. (2,3- or 3,4)-difluoro U-48800. 32
44	45		oooo. (2,3- or 3,4 or 2,4)-difluoro U-47700. 33
45	46		pppp. UF-17. 34
46		-	qqqq. U-47109. 35
47		-	rrrr. U-48520. 36 General Assembly Of North Carolina Session 2025
48		-	Page 2 House Bill 330-Second Edition
49		-	ssss. N,N-didesmethyl U-47700. 1
50		-	tttt. U-62066. 2
51		-	uuuu. Propyl U-47700. 3
52		-	vvvv. (2,3- or 3,4)-Ethylenedioxy U-51754. 4
53		-	wwww. 4-phenyl U-51754. 5
54		-	xxxx. N-desmethyl U-47700. 6
55		-	yyyy. (2,3- or 3,4)-Ethylenedioxy U-47700. 7
56		-	zzzz. N-methyl U-47931E. 8
57		-	aaaaa. (2,3- or 3,4)-Methylenedioxy U-47700. 9
58		-	bbbbb. U-69593. 10
59		-	ccccc. U-50488. 11
60		-	ddddd. U-48753E. 12
61		-	eeeee. U-47931E." 13
62		-	SECTION 1.(b) G.S. 90-89(1a) reads as rewritten: 14
63		-	"(1a) Fentanyl derivatives. – Unless specifically excepted, listed in another 15
64		-	schedule, or contained within a pharmaceutical product approved by the 16
65		-	United States Food and Drug Administration, any compound structurally 17
66		-	derived from N-[1-(2-phenylethyl)-4-piperidinyl]-N-phenylpropanamide 18
67		-	(Fentanyl) by any substitution on or replacement of the phenethyl group, any 19
68		-	substitution on the piperidine ring, any substitution on or replacement of the 20
69		-	propanamide group, any substitution on the anilido phenyl group, or any 21
70		-	combination of the above unless specifically excepted or listed in another 22
71		-	schedule to include their salts, isomers, and salts of isomers. Fentanyl 23
72		-	derivatives include, but are not limited to, the following: 24
	47	+	qqqq. U-47109. 35 General Assembly Of North Carolina Session 2025
	48	+	Page 2 House Bill 330-First Edition
	49	+	rrrr. U-48520. 1
	50	+	ssss. N,N-didesmethyl U-47700. 2
	51	+	tttt. U-62066. 3
	52	+	uuuu. Propyl U-47700. 4
	53	+	vvvv. (2,3- or 3,4)-Ethylenedioxy U-51754. 5
	54	+	wwww. 4-phenyl U-51754. 6
	55	+	xxxx. N-desmethyl U-47700. 7
	56	+	yyyy. (2,3- or 3,4)-Ethylenedioxy U-47700. 8
	57	+	zzzz. N-methyl U-47931E. 9
	58	+	aaaaa. (2,3- or 3,4)-Methylenedioxy U-47700. 10
	59	+	bbbbb. U-69593. 11
	60	+	ccccc. U-50488. 12
	61	+	ddddd. U-48753E. 13
	62	+	eeeee. U-47931E." 14
	63	+	SECTION 1.(b) G.S. 90-89(1a) reads as rewritten: 15
	64	+	"(1a) Fentanyl derivatives. – Unless specifically excepted, listed in another 16
	65	+	schedule, or contained within a pharmaceutical product approved by the 17
	66	+	United States Food and Drug Administration, any compound structurally 18
	67	+	derived from N-[1-(2-phenylethyl)-4-piperidinyl]-N-phenylpropanamide 19
	68	+	(Fentanyl) by any substitution on or replacement of the phenethyl group, any 20
	69	+	substitution on the piperidine ring, any substitution on or replacement of the 21
	70	+	propanamide group, any substitution on the anilido phenyl group, or any 22
	71	+	combination of the above unless specifically excepted or listed in another 23
	72	+	schedule to include their salts, isomers, and salts of isomers. Fentanyl 24
	73	+	derivatives include, but are not limited to, the following: 25
	74	+	… 26
	75	+	f.27
	76	+	N-(2-fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-propana28
	77	+	mide (also known as 2-fluorofentanyl).(also known as 29
	78	+	ortho-fluorofentanyl). 30
	79	+	g.31
	80	+	N-(3-fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-propana32
	81	+	mide (also known as 3-fluorofentanyl).(also known as 33
	82	+	meta-fluorofentanyl). 34
	83	+	… 35
	84	+	i.36
	85	+	N-(4-fluorophenyl)-2-methyl-N-[1-(2-phenylethyl)-4-piperidinyl]37
	86	+	-propanamide (also known as 4-fluoroisobutyryl fentanyl, 38
	87	+	4-FIBF).(also known as 4-fluoroisobutyryl fentanyl). 39
	88	+	j. N-(4-fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-butanamide 40
	89	+	(also known as 4-fluorobutyryl fentanyl, 4-FBF).(also known as 41
	90	+	4-fluorobutyryl fentanyl)." 42
	91	+	SECTION 1.(c) G.S. 90-89 is amended by adding a new subdivision to read: 43
	92	+	"(1b) Nitazene derivatives. – The N-substituted benzimidazole structural class, 44
	93	+	including any of the following derivatives, their salts, isomers, or salts of 45
	94	+	isomers unless specifically utilized as part of the manufacturing process by a 46
	95	+	commercial industry of a substance or material not intended for human 47
	96	+	ingestion or consumption, as a prescription administered under medical 48
	97	+	supervision, or for research at a recognized institution, whenever the existence 49
	98	+	of these salts, isomers, or salts of isomers is possible within the specific 50
	99	+	chemical designation or unless specifically excepted or listed in this or another 51 General Assembly Of North Carolina Session 2025
	100	+	House Bill 330-First Edition Page 3
	101	+	schedule, structurally derived from benzimidazole by substitution at the 1
	102	+	1-position nitrogen with an ethylamine group, and by substitution at the 2
	103	+	2-position carbon with a benzyl group, whether or not the compound is further 3
	104	+	modified in any of the following ways: 4
	105	+	a. By monoalkyl or dialkyl substitution on the 1'-nitrogen of the 5
	106	+	1-position ethylamine group, or by inclusion of the nitrogen in a cyclic 6
	107	+	structure. 7
	108	+	b. By substitution on the 2'-methylene carbon of the benzyl group by 8
	109	+	alkyl or carboxamide groups. 9
	110	+	c. By replacement of the 2'-methylene carbon group with an ethylbenzyl, 10
	111	+	thiophenol, or methoxybenzene group, which may be further 11
	112	+	substituted with alkyl, hydroxyl, alkoxy, acetoxy, halide, or sulfide 12
	113	+	groups. 13
	114	+	d. By substitution at the 2'-position, 3'-position, or 4'-position of the 14
	115	+	benzyl group, or both, with alkyl, hydroxyl, alkoxy, acetoxy, halide, 15
	116	+	or sulfide groups. 16
	117	+	e. By replacement of a phenyl hydrogen atom at either the 5-position or 17
	118	+	6-position of the benzimidazole core with a nitro, or primary amine 18
	119	+	group." 19
	120	+	SECTION 1.(d) G.S. 90-89(3)mm. reads as rewritten: 20
	121	+	"mm. 5-methoxy-N-methyl-N-propyltryptamine 21
	122	+	(5-MeO-MiPT).5-methoxy-N-methyl-N-isopropyltryptamine 22
	123	+	(5-MeO-MiPT)." 23
	124	+	SECTION 1.(e) G.S. 90-89(4) is amended by adding a new sub-subdivision to read: 24
	125	+	"j. Bromazolam." 25
	126	+	SECTION 1.(f) G.S. 90-89(5)j. reads as rewritten: 26
	127	+	"j. Substituted cathinones. A compound, other than bupropion, that is 27
	128	+	structurally derived from 2-amino-1-phenyl-1-propanone by 28
	129	+	modification in any of the following ways: (i) by substitution in the 29
	130	+	phenyl ring to any extent with alkyl, alkoxy, alkylenedioxy, haloalkyl, 30
	131	+	or halide substituents, whether or not further substituted in the phenyl 31
	132	+	ring by one or more other univalent substituents; (ii) by substitution at 32
	133	+	the 3-position to any extent; or (iii) by substitution at the nitrogen atom 33
	134	+	with alkyl, dialkyl, benzyl, cycloalkyl, or methoxybenzyl groups or by 34
	135	+	inclusion of the nitrogen atom in a cyclic structure. For the purpose of 35
	136	+	this paragraph, the term "isomer" includes the optical, positional, or 36
	137	+	geometric isomer." 37
	138	+	SECTION 1.(g) G.S. 90-89(7) reads as rewritten: 38
	139	+	"(7) Synthetic cannabinoids. – Any quantity of any synthetic chemical compound 39
	140	+	that (i) is a cannabinoid receptor agonist and mimics the pharmacological 40
	141	+	effect of naturally occurring substances or (ii) has a stimulant, depressant, or 41
	142	+	hallucinogenic effect on the central nervous system that is not listed as a 42
	143	+	controlled substance in Schedules I through V, and is not an FDA-approved 43
	144	+	drug. Synthetic cannabinoids include, but are not limited to, the substances 44
	145	+	listed in sub-subdivisions a. through p. v. of this subdivision and any substance 45
	146	+	that contains any quantity of their salts, isomers (whether optical, positional, 46
	147	+	or geometric), homologues, and salts of isomers and homologues, unless 47
	148	+	specifically excepted, whenever the existence of these salts, isomers, 48
	149	+	homologues, and salts of isomers and homologues is possible within the 49
	150	+	specific chemical designation. The following substances are examples of 50 General Assembly Of North Carolina Session 2025
	151	+	Page 4 House Bill 330-First Edition
	152	+	synthetic cannabinoids and are not intended to be inclusive of the substances 1
	153	+	included in this Schedule: 2
	154	+	… 3
	155	+	l. Indole carboxamides. Any compound structurally derived from 4
	156	+	1H-indole-3-carboxamide or 1H-indole-2-carboxamide substituted in 5
	157	+	one or both of the following ways: 6
	158	+	1. At the nitrogen atom of the indole ring by an alkyl, haloalkyl, 7
	159	+	cyanoalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 8
	160	+	1-(N-methyl-2-piperidinyl)methyl, 2-(4-morpholinyl)ethyl, 9
	161	+	1-(N-methyl-2-pyrrolidinyl)methyl, 10
	162	+	1-(N-methyl-3-morpholinyl)methyl, tetrahydropyranylmethyl, 11
	163	+	benzyl, or halo benzyl group; andor 12
	164	+	2. At the nitrogen of the carboxamide by a phenyl, benzyl, 13
	165	+	naphthyl, adamantyl, cyclopropyl, or propionaldehyde 14
	166	+	group;group, or methyl 3,3-dimethyl-butanoate group; 15
	167	+	whether or not the compound is further modified to any extent 16
	168	+	in the following ways: (i) substitution to the indole ring to any 17
	169	+	extent, (ii) substitution to the phenyl, benzyl, naphthyl, 18
	170	+	adamantyl, cyclopropyl, or propionaldehyde group to any 19
	171	+	extent, (iii) a nitrogen heterocyclic analog of the indole ring, or 20
	172	+	(iv) a nitrogen heterocyclic analog of the phenyl, benzyl, 21
	173	+	naphthyl, adamantyl, or cyclopropyl ring. Substances in this 22
	174	+	class include, but are not limited to: SDB-001 and 23
	175	+	STS-135.STS-135 and MDMB-ICA. 24
73	176		… 25
74		-	f.26
75		-	N-(2-fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-propana27
76		-	mide (also known as 2-fluorofentanyl).(also known as 28
77		-	ortho-fluorofentanyl). 29
78		-	g.30
79		-	N-(3-fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-propana31
80		-	mide (also known as 3-fluorofentanyl).(also known as 32
81		-	meta-fluorofentanyl). 33
82		-	… 34
83		-	i.35
84		-	N-(4-fluorophenyl)-2-methyl-N-[1-(2-phenylethyl)-4-piperidinyl]36
85		-	-propanamide (also known as 4-fluoroisobutyryl fentanyl, 37
86		-	4-FIBF).(also known as 4-fluoroisobutyryl fentanyl). 38
87		-	j. N-(4-fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-butanamide 39
88		-	(also known as 4-fluorobutyryl fentanyl, 4-FBF).(also known as 40
89		-	para-fluorobutyryl fentanyl)." 41
90		-	SECTION 1.(c) G.S. 90-89 is amended by adding a new subdivision to read: 42
91		-	"(1b) Nitazene derivatives. – The N-substituted benzimidazole structural class, 43
92		-	including any of the following derivatives, their salts, isomers, or salts of 44
93		-	isomers unless specifically utilized as part of the manufacturing process by a 45
94		-	commercial industry of a substance or material not intended for human 46
95		-	ingestion or consumption, as a prescription administered under medical 47
96		-	supervision, or for research at a recognized institution, whenever the existence 48
97		-	of these salts, isomers, or salts of isomers is possible within the specific 49
98		-	chemical designation or unless specifically excepted or listed in this or another 50
99		-	schedule, structurally derived from benzimidazole by substitution at the 51 General Assembly Of North Carolina Session 2025
100		-	House Bill 330-Second Edition Page 3
101		-	1-position nitrogen with an ethylamine group, and by substitution at the 1
102		-	2-position carbon with a benzyl group, whether or not the compound is further 2
103		-	modified in any of the following ways: 3
104		-	a. By monoalkyl or dialkyl substitution on the 1'-nitrogen of the 4
105		-	1-position ethylamine group, or by inclusion of the nitrogen in a cyclic 5
106		-	structure. 6
107		-	b. By substitution on the 2'-methylene carbon of the benzyl group by 7
108		-	alkyl or carboxamide groups. 8
109		-	c. By replacement of the 2'-methylene carbon group with an ethylbenzyl, 9
110		-	thiophenol, or methoxybenzene group, which may be further 10
111		-	substituted with alkyl, hydroxyl, alkoxy, acetoxy, halide, or sulfide 11
112		-	groups. 12
113		-	d. By substitution at the 2'-position, 3'-position, or 4'-position of the 13
114		-	benzyl group, or both, with alkyl, hydroxyl, alkoxy, acetoxy, halide, 14
115		-	or sulfide groups. 15
116		-	e. By replacement of a phenyl hydrogen atom at either the 5-position or 16
117		-	6-position of the benzimidazole core with a nitro, or primary amine 17
118		-	group." 18
119		-	SECTION 1.(d) G.S. 90-89(3)mm. reads as rewritten: 19
120		-	"mm. 5-methoxy-N-methyl-N-propyltryptamine 20
121		-	(5-MeO-MiPT).5-methoxy-N-methyl-N-isopropyltryptamine 21
122		-	(5-MeO-MiPT)." 22
123		-	SECTION 1.(e) G.S. 90-89(4) is amended by adding a new sub-subdivision to read: 23
124		-	"j. Bromazolam." 24
125		-	SECTION 1.(f) G.S. 90-89(5)j. reads as rewritten: 25
126		-	"j. Substituted cathinones. A compound, other than bupropion, that is 26
127		-	structurally derived from 2-amino-1-phenyl-1-propanone by 27
128		-	modification in any of the following ways: (i) by substitution in the 28
129		-	phenyl ring to any extent with alkyl, alkoxy, alkylenedioxy, haloalkyl, 29
130		-	or halide substituents, whether or not further substituted in the phenyl 30
131		-	ring by one or more other univalent substituents; (ii) by substitution at 31
132		-	the 3-position to any extent; or (iii) by substitution at the nitrogen atom 32
133		-	with alkyl, dialkyl, benzyl, cycloalkyl, or methoxybenzyl groups or by 33
134		-	inclusion of the nitrogen atom in a cyclic structure. For the purpose of 34
135		-	this paragraph, the term "isomer" includes the optical, positional, or 35
136		-	geometric isomer." 36
137		-	SECTION 1.(g) G.S. 90-89(7) reads as rewritten: 37
138		-	"(7) Synthetic cannabinoids. – Any quantity of any synthetic chemical compound 38
139		-	that (i) is a cannabinoid receptor agonist and mimics the pharmacological 39
140		-	effect of naturally occurring substances or (ii) has a stimulant, depressant, or 40
141		-	hallucinogenic effect on the central nervous system that is not listed as a 41
142		-	controlled substance in Schedules I through V, and is not an FDA-approved 42
143		-	drug. Synthetic cannabinoids include, but are not limited to, the substances 43
144		-	listed in sub-subdivisions a. through p. v. of this subdivision and any substance 44
145		-	that contains any quantity of their salts, isomers (whether optical, positional, 45
146		-	or geometric), homologues, and salts of isomers and homologues, unless 46
147		-	specifically excepted, whenever the existence of these salts, isomers, 47
148		-	homologues, and salts of isomers and homologues is possible within the 48
149		-	specific chemical designation. The following substances are examples of 49
150		-	synthetic cannabinoids and are not intended to be inclusive of the substances 50
151		-	included in this Schedule: 51 General Assembly Of North Carolina Session 2025
152		-	Page 4 House Bill 330-Second Edition
153		-	… 1
154		-	l. Indole carboxamides. Any compound structurally derived from 2
155		-	1H-indole-3-carboxamide or 1H-indole-2-carboxamide substituted in 3
156		-	one or both of the following ways: 4
157		-	1. At the nitrogen atom of the indole ring by an alkyl, haloalkyl, 5
158		-	cyanoalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 6
159		-	1-(N-methyl-2-piperidinyl)methyl, 2-(4-morpholinyl)ethyl, 7
160		-	1-(N-methyl-2-pyrrolidinyl)methyl, 8
161		-	1-(N-methyl-3-morpholinyl)methyl, tetrahydropyranylmethyl, 9
162		-	benzyl, or halo benzyl group; andor 10
163		-	2. At the nitrogen of the carboxamide by a phenyl, benzyl, 11
164		-	naphthyl, adamantyl, cyclopropyl, or propionaldehyde 12
165		-	group;group, or methyl 3,3-dimethyl-butanoate group; 13
166		-	whether or not the compound is further modified to any extent 14
167		-	in the following ways: (i) substitution to the indole ring to any 15
168		-	extent, (ii) substitution to the phenyl, benzyl, naphthyl, 16
169		-	adamantyl, cyclopropyl, or propionaldehyde group to any 17
170		-	extent, (iii) a nitrogen heterocyclic analog of the indole ring, or 18
171		-	(iv) a nitrogen heterocyclic analog of the phenyl, benzyl, 19
172		-	naphthyl, adamantyl, or cyclopropyl ring. Substances in this 20
173		-	class include, but are not limited to: SDB-001 and 21
174		-	STS-135.STS-135 and MDMB-ICA. 22
175		-	… 23
176		-	n. Indazole carboxaldehydes. Any compound structurally derived from 24
177		-	1H-indazole-3-carboxaldehyde or 1H-indazole-2-carboxaldehyde 25
178		-	substituted in both of the following ways: 26
179		-	… 27
180		-	2. At the carbon of the carboxaldehyde by a phenyl, benzyl, 28
181		-	naphthyl, adamantyl, cyclopropyl, or propionaldehyde group; 29
182		-	whether or not the compound is further modified to any extent 30
183		-	in the following ways: (i) substitution to the indazole ring to 31
184		-	any extent, (ii) substitution to the phenyl, benzyl, naphthyl, 32
185		-	adamantyl, cyclopropyl, or propionaldehyde group to any 33
186		-	extent, (iii) a nitrogen heterocyclic analog of the indazole ring, 34
187		-	or (iv) a nitrogen heterocyclic analog of the phenyl, benzyl, 35
188		-	naphthyl, adamantyl, or cyclopropyl ring. 36
189		-	o. Indazole carboxamides. Any compound structurally derived from 37
190		-	1H-indazole-3-carboxamide or 1H -indazole-2-carboxamide 38
191		-	substituted in one or both of the following ways: 39
192		-	1. At the nitrogen atom of the indazole ring by an alkyl, haloalkyl, 40
193		-	cyanoalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 41
194		-	1-(N-methyl-2-piperidinyl)methyl, 2-(4-morpholinyl)ethyl, 42
195		-	1-(N-methyl-2-pyrrolidinyl)methyl, 43
196		-	1-(N-methyl-3-morpholinyl)methyl, tetrahydropyranylmethyl, 44
197		-	benzyl, or halo benzyl group; andor 45
198		-	2. At the nitrogen of the carboxamide by a phenyl, benzyl, 46
199		-	naphthyl, adamantyl, cyclopropyl, or propionaldehyde 47
200		-	group;group, or methyl 3,3-dimethyl-butanoate group; 48
201		-	whether or not the compound is further modified to any extent in the 49
202		-	following ways: (i) substitution to the indazole ring to any extent, (ii) 50
203		-	substitution to the phenyl, benzyl, naphthyl, adamantyl, cyclopropyl, 51 General Assembly Of North Carolina Session 2025
204		-	House Bill 330-Second Edition Page 5
205		-	or propionaldehyde group to any extent, (iii) a nitrogen heterocyclic 1
206		-	analog of the indazole ring, or (iv) a nitrogen heterocyclic analog of 2
207		-	the phenyl, benzyl, naphthyl, adamantyl, or cyclopropyl ring. 3
208		-	Substances in this class include, but are not limited to: AKB-48, 4
209		-	fluoro-AKB-48, APINCACA, AB-PINACA, AB-FUBINACA, 5
210		-	ADB-FUBINACA, and ADB-PINACA.ADB-PINACA, 6
211		-	ADB-INACA, MDMB -INACA, MDMB -5Me-INACA, and 7
212		-	MDMB-5Br-INACA. 8
213		-	… 9
214		-	s. Oxindoles. Any compound structurally derived from 10
215		-	3-hydrazonoindolin-2-one substituted in one or both of the following 11
216		-	ways: 12
217		-	1. At the nitrogen atom of the oxoindole ring by an alkyl, 13
218		-	haloalkyl, cyanoalkyl, alkenyl, cycloalkylmethyl, 14
219		-	cycloalkylethyl; or 15
220		-	2. At the nitrogen of the hydrazide by a phenyl, benzyl, naphthyl, 16
221		-	adamantyl, cyclopropyl, or propionaldehyde group; 17
222		-	whether or not the compound is further modified to any extent 18
223		-	in the following ways: (i) substitution to the oxoindole ring to 19
224		-	any extent or (ii) substitution to the phenyl, benzyl, naphthyl, 20
225		-	adamantyl, cyclopropyl, or propionaldehyde group to any 21
226		-	extent. Substances in this class include, but are not limited to: 22
227		-	BZO-POXIZID, BZO-HEXOXIZIDE, 5F-BZO-POXIZIDE. 23
228		-	t. Indole acetamides. Any compound structurally derived from 24
229		-	1H-indole-3-acetamide or 1H-indole-2-acetamide substituted in one or 25
230		-	both of the following ways: 26
231		-	1. At the nitrogen atom of the indole ring by an alkyl, haloalkyl, 27
232		-	cyanoalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 28
233		-	1-(N-methyl-2-piperidinyl)methyl, 2-(4-morpholinyl)ethyl, 29
234		-	1-(N-methyl-2-pyrrolidinyl)methyl, 30
235		-	1-(N-methyl-3-morpholinyl)methyl, tetrahydropyranylmethyl, 31
236		-	benzyl, or halo benzyl group; or 32
237		-	2. At the nitrogen of the acetamide by a phenyl, benzyl, naphthyl, 33
238		-	adamantyl, cyclopropyl, or propionaldehyde group; 34
239		-	whether or not the compound is further modified to any extent 35
240		-	in the following ways: (i) substitution to the indole ring to any 36
241		-	extent, (ii) substitution to the phenyl, benzyl, naphthyl, 37
242		-	adamantyl, cyclopropyl, or propionaldehyde group to any 38
243		-	extent, (iii) a nitrogen heterocyclic analog of the indole ring, or 39
244		-	(iv) a nitrogen heterocyclic analog of the phenyl, benzyl, 40
245		-	naphthyl, adamantyl, or cyclopropyl ring. Substances in this 41
246		-	class include, but are not limited to: AFUBIATA, CH-PIATA, 42
247		-	AB-CHMIATA, ADB-FUBIATA. 43
248		-	u. Indazole acetaldehydes. Any compound structurally derived from 44
249		-	1H-indazol-3-ylacetaldehyde or 1H-indazol-2-ylacetaldehyde 45
250		-	substituted in one or both of the following ways: 46
251		-	1. At the nitrogen atom of the indazole ring by an alkyl, haloalkyl, 47
252		-	cyanoalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 48
253		-	1-(N-methyl-2-piperidinyl)methyl, 2-(4-morpholinyl)ethyl, 49
254		-	1-(N-methyl-2-pyrrolidinyl)methyl, 50 General Assembly Of North Carolina Session 2025
255		-	Page 6 House Bill 330-Second Edition
256		-	1-(N-methyl-3-morpholinyl)methyl, tetrahydropyranylmethyl, 1
257		-	benzyl, or halo benzyl group; or 2
258		-	2. At the nitrogen of the carboxamide by a phenyl, benzyl, 3
259		-	naphthyl, adamantyl, cyclopropyl, or propionaldehyde group; 4
260		-	whether or not the compound is further modified to any extent 5
261		-	in the following ways: (i) substitution to the indazole ring to 6
262		-	any extent, (ii) substitution to the phenyl, benzyl, naphthyl, 7
263		-	adamantyl, cyclopropyl, or propionaldehyde group to any 8
264		-	extent, (iii) a nitrogen heterocyclic analog of the indazole ring, 9
265		-	or (iv) a nitrogen heterocyclic analog of the phenyl, benzyl, 10
266		-	naphthyl, adamantyl, or cyclopropyl ring. Substances in this 11
267		-	class include, but are not limited to: ADB-BUTINAATA, 12
268		-	ADB-FUBINAATA. 13
269		-	v. Pyrazoles. Any compound structurally derived from 1H-pyrazole 14
270		-	substituted in all of the following ways: 15
271		-	1. At the 1 position of the pyrazole ring by an alkyl, haloalkyl, or 16
272		-	alkenyl group. 17
273		-	2. At the 3 position of the pyrazole ring by a halo benzyl or 18
274		-	propionaldehyde group. 19
275		-	3. At the 5 position of the pyrazole ring by a halo benzyl or 20
276		-	propionaldehyde group; 21
277		-	whether or not the compound is further modified by a 22
278		-	substitution to the propionaldehyde group to any extent. 23
279		-	Substances in this class include, but are not limited to: 24
280		-	3,5-ADB-4en-PFUPPYCA, 5-fluoro-3,5-AB-PFUPPYCA." 25
281		-	SECTION 1.(h) G.S. 90-90(2)h1. reads as rewritten: 26
282		-	"h1. Fentanyl immediate pr ecursor chemical, 27
283		-	4-anilino-N-phenethyl-4-piperidine 28
284		-	(ANPP).4-anilino-N-phenethylpiperdine (ANPP)." 29
285		-	SECTION 1.(i) G.S. 90-91(k)11. reads as rewritten: 30
286		-	"11. Dehydrochlormethyltestosterone,Dehydrochloromethyltestosterone," 31
287		-	SECTION 1.(j) G.S. 90-91(k)16. reads as rewritten: 32
288		-	"16. Mesterolene,Mesterolone," 33
289		-	SECTION 2. This act is effective when it becomes law. 34
	177	+	n. Indazole carboxaldehydes. Any compound structurally derived from 26
	178	+	1H-indazole-3-carboxaldehyde or 1H-indazole-2-carboxaldehyde 27
	179	+	substituted in both of the following ways: 28
	180	+	… 29
	181	+	2. At the carbon of the carboxaldehyde by a phenyl, benzyl, 30
	182	+	naphthyl, adamantyl, cyclopropyl, or propionaldehyde group; 31
	183	+	whether or not the compound is further modified to any extent 32
	184	+	in the following ways: (i) substitution to the indazole ring to 33
	185	+	any extent, (ii) substitution to the phenyl, benzyl, naphthyl, 34
	186	+	adamantyl, cyclopropyl, or propionaldehyde group to any 35
	187	+	extent, (iii) a nitrogen heterocyclic analog of the indazole ring, 36
	188	+	or (iv) a nitrogen heterocyclic analog of the phenyl, benzyl, 37
	189	+	naphthyl, adamantyl, or cyclopropyl ring. 38
	190	+	o. Indazole carboxamides. Any compound structurally derived from 39
	191	+	1H-indazole-3-carboxamide or 1H -indazole-2-carboxamide 40
	192	+	substituted in one or both of the following ways: 41
	193	+	1. At the nitrogen atom of the indazole ring by an alkyl, haloalkyl, 42
	194	+	cyanoalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 43
	195	+	1-(N-methyl-2-piperidinyl)methyl, 2-(4-morpholinyl)ethyl, 44
	196	+	1-(N-methyl-2-pyrrolidinyl)methyl, 45
	197	+	1-(N-methyl-3-morpholinyl)methyl, tetrahydropyranylmethyl, 46
	198	+	benzyl, or halo benzyl group; andor 47
	199	+	2. At the nitrogen of the carboxamide by a phenyl, benzyl, 48
	200	+	naphthyl, adamantyl, cyclopropyl, or propionaldehyde 49
	201	+	group;group, or methyl 3,3-dimethyl-butanoate group; 50 General Assembly Of North Carolina Session 2025
	202	+	House Bill 330-First Edition Page 5
	203	+	whether or not the compound is further modified to any extent 1
	204	+	in the following ways: (i) substitution to the indazole ring to 2
	205	+	any extent, (ii) substitution to the phenyl, benzyl, naphthyl, 3
	206	+	adamantyl, cyclopropyl, or propionaldehyde group to any 4
	207	+	extent, (iii) a nitrogen heterocyclic analog of the indazole ring, 5
	208	+	or (iv) a nitrogen heterocyclic analog of the phenyl, benzyl, 6
	209	+	naphthyl, adamantyl, or cyclopropyl ring. Substances in this 7
	210	+	class include, but are not limited to: AKB-48, fluoro-AKB-48, 8
	211	+	APINCACA, AB-PINACA, AB -FUBINACA, 9
	212	+	ADB-FUBINACA, and ADB-PINACA.ADB-PINACA, 10
	213	+	ADB-INACA, MDMB-INACA, MDMB-5Me-INACA, and 11
	214	+	MDMB-5Br-INACA. 12
	215	+	… 13
	216	+	s. Oxindoles. Any compound structurally derived from 14
	217	+	3-hydrazonoindolin-2-one substituted in one or both of the following 15
	218	+	ways: 16
	219	+	1. At the nitrogen atom of the oxoindole ring by an alkyl, 17
	220	+	haloalkyl, cyanoalkyl, alkenyl, cycloalkylmethyl, 18
	221	+	cycloalkylethyl; or 19
	222	+	2. At the nitrogen of the hydrazide by a phenyl, benzyl, naphthyl, 20
	223	+	adamantyl, cyclopropyl, or propionaldehyde group; 21
	224	+	whether or not the compound is further modified to any extent 22
	225	+	in the following ways: (i) substitution to the oxoindole ring to 23
	226	+	any extent or (ii) substitution to the phenyl, benzyl, naphthyl, 24
	227	+	adamantyl, cyclopropyl, or propionaldehyde group to any 25
	228	+	extent. Substances in this class include, but are not limited to: 26
	229	+	BZO-POXIZID, BZO-HEXOXIZIDE, 5F-BZO-POXIZIDE. 27
	230	+	t. Indole acetamides. Any compound structurally derived from 28
	231	+	1H-indole-3-acetamide or 1H-indole-2-acetamide substituted in one or 29
	232	+	both of the following ways: 30
	233	+	1. At the nitrogen atom of the indole ring by an alkyl, haloalkyl, 31
	234	+	cyanoalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 32
	235	+	1-(N-methyl-2-piperidinyl)methyl, 2-(4-morpholinyl)ethyl, 33
	236	+	1-(N-methyl-2-pyrrolidinyl)methyl, 34
	237	+	1-(N-methyl-3-morpholinyl)methyl, tetrahydropyranylmethyl, 35
	238	+	benzyl, or halo benzyl group; or 36
	239	+	2. At the nitrogen of the acetamide by a phenyl, benzyl, naphthyl, 37
	240	+	adamantyl, cyclopropyl, or propionaldehyde group; 38
	241	+	whether or not the compound is further modified to any extent 39
	242	+	in the following ways: (i) substitution to the indole ring to any 40
	243	+	extent, (ii) substitution to the phenyl, benzyl, naphthyl, 41
	244	+	adamantyl, cyclopropyl, or propionaldehyde group to any 42
	245	+	extent, (iii) a nitrogen heterocyclic analog of the indole ring, or 43
	246	+	(iv) a nitrogen heterocyclic analog of the phenyl, benzyl, 44
	247	+	naphthyl, adamantyl, or cyclopropyl ring. Substances in this 45
	248	+	class include, but are not limited to: AFUBIATA, CH-PIATA, 46
	249	+	AB-CHMIATA, ADB-FUBIATA. 47
	250	+	u. Indazole acetaldehydes. Any compound structurally derived from 48
	251	+	1H-indazol-3-ylacetaldehyde or 1H -indazol-2-ylacetaldehyde 49
	252	+	substituted in one or both of the following ways: 50 General Assembly Of North Carolina Session 2025
	253	+	Page 6 House Bill 330-First Edition
	254	+	1. At the nitrogen atom of the indazole ring by an alkyl, haloalkyl, 1
	255	+	cyanoalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 2
	256	+	1-(N-methyl-2-piperidinyl)methyl, 2-(4-morpholinyl)ethyl, 3
	257	+	1-(N-methyl-2-pyrrolidinyl)methyl, 4
	258	+	1-(N-methyl-3-morpholinyl)methyl, tetrahydropyranylmethyl, 5
	259	+	benzyl, or halo benzyl group; or 6
	260	+	2. At the nitrogen of the carboxamide by a phenyl, benzyl, 7
	261	+	naphthyl, adamantyl, cyclopropyl, or propionaldehyde group; 8
	262	+	whether or not the compound is further modified to any extent 9
	263	+	in the following ways: (i) substitution to the indazole ring to 10
	264	+	any extent, (ii) substitution to the phenyl, benzyl, naphthyl, 11
	265	+	adamantyl, cyclopropyl, or propionaldehyde group to any 12
	266	+	extent, (iii) a nitrogen heterocyclic analog of the indazole ring, 13
	267	+	or (iv) a nitrogen heterocyclic analog of the phenyl, benzyl, 14
	268	+	naphthyl, adamantyl, or cyclopropyl ring. Substances in this 15
	269	+	class include, but are not limited to: ADB-BUTINAATA, 16
	270	+	ADB-FUBINAATA. 17
	271	+	v. Pyrazoles. Any compound structurally derived from 1H-pyrazole 18
	272	+	substituted in all of the following ways: 19
	273	+	1. At the 1 position of the pyrazole ring by an alkyl, haloalkyl, or 20
	274	+	alkenyl group. 21
	275	+	2. At the 3 position of the pyrazole ring by a halo benzyl or 22
	276	+	propionaldehyde group. 23
	277	+	3. At the 5 position of the pyrazole ring by a halo benzyl or 24
	278	+	propionaldehyde group; 25
	279	+	whether or not the compound is further modified by a 26
	280	+	substitution to the propionaldehyde group to any extent. 27
	281	+	Substances in this class include, but are not limited to: 28
	282	+	3,5-ADB-4en-PFUPPYCA, 5-fluoro-3,5-AB-PFUPPYCA." 29
	283	+	SECTION 1.(h) G.S. 90-90(2)h1. reads as rewritten: 30
	284	+	"h1. Fentanyl immediate precursor chemical, 31
	285	+	4-anilino-N-phenethyl-4-piperidine 32
	286	+	(ANPP).4-anilino-N-phenethylpiperdine (ANPP)." 33
	287	+	SECTION 1.(i) G.S. 90-91(k)11. reads as rewritten: 34
	288	+	"11. Dehydrochlormethyltestosterone,Dehydrochloromethyltestosterone," 35
	289	+	SECTION 1.(j) G.S. 90-91(k)16. reads as rewritten: 36
	290	+	"16. Mesterolene,Mesterolone," 37
	291	+	SECTION 2. This act is effective when it becomes law. 38