North Carolina 2025-2026 Regular Session

North Carolina Senate Bill S450 Compare Versions

Version 1 (Old)

Version 2 (New)

Old	New		Differences
1	1		GENERAL ASSEMBLY OF NORTH CAROLINA
2	2		SESSION 2025
3		-	S 1
4		-	SENATE BILL 450
	3	+	S D
	4	+	SENATE BILL DRS15191-NI-1A
	5	+
5	6
6	7
7	8		Short Title: Novel Opioid Control Act of 2025. (Public)
8	9		Sponsors: Senators McInnis, Lazzara, and Sawyer (Primary Sponsors).
9		-	Referred to: ~~Rules and Operations of the Senate~~
10		-	~~March 25, 2025~~
11		-	~~S450 -v-1~~
	10	+	Referred to:
	11	+
	12	+	DRS15191 -NI-1A
12	13		A BILL TO BE ENTITLED 1
13	14		AN ACT TO UPDATE THE CONTROLLED SUBSTANCES ACT. 2
14	15		The General Assembly of North Carolina enacts: 3
15	16		SECTION 1.(a) G.S. 90-89(1) reads as rewritten: 4
16	17		"(1) Opiates. – Any of the following opiates or opioids, including the isomers, 5
17	18		esters, ethers, salts and salts of isomers, esters, and ethers, unless specifically 6
18	19		excepted, or listed in another schedule, whenever the existence of such 7
19	20		isomers, esters, ethers, and salts is possible within the specific chemical 8
20	21		designation: 9
21	22		… 10
22	23		rrr. Brorphine. 11
23	24		sss. AP-237. 12
24	25		ttt. 2-methyl AP-237. 13
25	26		uuu. (ortho, meta, or para)-methyl AP-237. 14
26	27		vvv. AP-238. 15
27	28		www. (ortho, meta, or para)-hydroxy 2-methyl AP-237. 16
28	29		xxx. 2-Naphthyl U-47700. 17
29	30		yyy. 1-Naphthyl U-47700. 18
30	31		zzz. 4-(Trifluoromethyl) U-47700. 19
31	32		aaaa. Methoxy U-47700. 20
32	33		bbbb. Furanyl UF-17. 21
33	34		cccc. Cyclopropyl U-47700. 22
34	35		dddd. Phenyl U-47700. 23
35	36		eeee. Ethyl U-47700. 24
36	37		ffff. (2,3- or 3,4)-difluoro-N,N-didesmethyl U-47700. 25
37	38		gggg. (2,3- or 3,4)-difluoro U-49900. 26
38	39		hhhh. (2,3- or 3,4)-difluoro-N-desmethyl U-47700. 27
39	40		iiii. 4-fluoro U-47931E. 28
40	41		jjjj. (2,3- or 3,4)-difluoro U-51754. 29
41	42		kkkk. (2,3- or 3,4)-difluoro Isopropyl U-47700. 30
42	43		llll. (2,3- or 3,4)-difluoro Propyl U-47700. 31
43	44		mmmm. (2,3- or 3,4)-difluoro U-50488. 32
44	45		nnnn. (2,3- or 3,4)-difluoro U-48800. 33
45	46		oooo. (2,3- or 3,4 or 2,4)-difluoro U-47700. 34
46	47		pppp. UF-17. 35
47		-	qqqq. U-47109. 36 General Assembly Of North Carolina Session 2025
48		-	Page 2 Senate Bill 450-First Edition
	48	+	qqqq. U-47109. 36
	49	+	FILED SENATE
	50	+	Mar 24, 2025
	51	+	S.B. 450
	52	+	PRINCIPAL CLERK General Assembly Of North Carolina Session 2025
	53	+	Page 2 DRS15191-NI-1A
49	54		rrrr. U-48520. 1
50	55		ssss. N,N-didesmethyl U-47700. 2
51	56		tttt. U-62066. 3
52	57		uuuu. Propyl U-47700. 4
53	58		vvvv. (2,3- or 3,4)-Ethylenedioxy U-51754. 5
54	59		wwww. 4-phenyl U-51754. 6
55	60		xxxx. N-desmethyl U-47700. 7
56	61		yyyy. (2,3- or 3,4)-Ethylenedioxy U-47700. 8
57	62		zzzz. N-methyl U-47931E. 9
58	63		aaaaa. (2,3- or 3,4)-Methylenedioxy U-47700. 10
59	64		bbbbb. U-69593. 11
60	65		ccccc. U-50488. 12
61	66		ddddd. U-48753E. 13
62	67		eeeee. U-47931E. 14
63	68		fffff. Butonitazene. 15
64	69		ggggg. Etodesnitazene (also known as Etonitazepyne). 16
65	70		hhhhh. Flunitazene. 17
66	71		iiiii. Metodesnitazene. 18
67	72		jjjjj. N-Pyrrolidino Etonitazene. 19
68	73		kkkkk. Protonitazene." 20
69	74		SECTION 1.(b) G.S. 90-89(1a) reads as rewritten: 21
70	75		"(1a) Fentanyl derivatives. – Unless specifically excepted, listed in another 22
71	76		schedule, or contained within a pharmaceutical product approved by the 23
72	77		United States Food and Drug Administration, any compound structurally 24
73	78		derived from N-[1-(2-phenylethyl)-4-piperidinyl]-N-phenylpropanamide 25
74	79		(Fentanyl) by any substitution on or replacement of the phenethyl group, any 26
75	80		substitution on the piperidine ring, any substitution on or replacement of the 27
76	81		propanamide group, any substitution on the anilido phenyl group, or any 28
77	82		combination of the above unless specifically excepted or listed in another 29
78	83		schedule to include their salts, isomers, and salts of isomers. Fentanyl 30
79	84		derivatives include, but are not limited to, the following: 31
80	85		… 32
81	86		f.33
82	87		N-(2-fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-propana34
83	88		mide (also known as 2-fluorofentanyl).(also known as 35
84	89		ortho-fluorofentanyl). 36
85	90		g.37
86	91		N-(3-fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-propana38
87	92		mide (also known as 3-fluorofentanyl).(also known as 39
88	93		meta-fluorofentanyl). 40
89	94		h.41
90	95		N-(1-phenethylpiperidin-4-yl)-N-phenyltetrahydrofuran-2-carbox42
91	96		amide (also known as tetrahydrofuran fentanyl). 43
92	97		i.44
93	98		N-(4-fluorophenyl)-2-methyl-N-[1-(2-phenylethyl)-4-piperidinyl]45
94	99		-propanamid e (also known as 4-fluoroisobutyryl fentanyl, 46
95	100		4-FIBF).(also known as 4-fluoroisobutyryl fentanyl). 47
96	101		j. N-(4-fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-butanamide 48
97	102		(also known as 4-fluorobutyryl fentanyl, 4-FBF).(also known as 49
98	103		4-fluorobutyryl fentanyl)." 50
99	104		SECTION 1.(c) G.S. 90-89 is amended by adding a new subdivision to read: 51 General Assembly Of North Carolina Session 2025
100		-	~~Senate Bill 450-First Edition~~ Page 3
	105	+	DRS15191-NI-1A Page 3
101	106		"(1b) Nitazene derivatives. – The N-substituted benzimidazole structural class, 1
102	107		including any of the following derivatives, their salts, isomers, or salts of 2
103	108		isomers unless specifically utilized as part of the manufacturing process by a 3
104	109		commercial industry of a substance or material not intended for human 4
105	110		ingestion or consumption, as a prescription administered under medical 5
106	111		supervision, or for research at a recognized institution, whenever the existence 6
107	112		of these salts, isomers, or salts of isomers is possible within the specific 7
108	113		chemical designation or unless specifically excepted or listed in this or another 8
109	114		schedule, structurally derived from benzimidazole by substitution at the 9
110	115		1-position nitrogen with an ethylamine group, and by substitution at the 10
111	116		2-position carbon with a benzyl group, whether or not the compound is further 11
112	117		modified in any of the following ways: 12
113	118		a. By monoalkyl or dialkyl substitution on the 1'-nitrogen of the 13
114	119		1-position ethylamine group, or by inclusion of the nitrogen in a cyclic 14
115	120		structure; 15
116	121		b. By substitution on the 2'-methylene carbon of the benzyl group by 16
117	122		alkyl or carboxamide groups; 17
118	123		c. By replacement of the 2'-methylene carbon group with an ethylbenzyl, 18
119	124		thiophenol, or methoxybenzene group, which may be further 19
120	125		substituted with alkyl, hydroxyl, alkoxy, acetoxy, halide, or sulfide 20
121	126		groups; 21
122	127		d. By substitution at the 2'-position, 3'-position, or 4'-position of the 22
123	128		benzyl group, or both, with alkyl, hydroxyl, alkoxy, acetoxy, halide, 23
124	129		or sulfide groups; and 24
125	130		e. By replacement of a phenyl hydrogen atom at either the 5-position or 25
126	131		6-position of the benzimidazole core with a nitro, or primary amine 26
127	132		group." 27
128	133		SECTION 1.(d) G.S. 90-89(3)mm. reads as rewritten: 28
129	134		"mm. 5-methoxy-N-methyl-N-propyltryptamine 29
130	135		5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT)." 30
131	136		SECTION 1.(e) G.S. 90-89(5)j. reads as rewritten: 31
132	137		"j. Substituted cathinones. A compound, other than bupropion, that is 32
133	138		structurally derived from 2-amino-1-phenyl-1-propanone by 33
134	139		modification in any of the following ways: (i) by substitution in the 34
135	140		phenyl ring to any extent with alkyl, alkoxy, alkylenedioxy, haloalkyl, 35
136	141		or halide substituents, whether or not further substituted in the phenyl 36
137	142		ring by one or more other univalent substituents; (ii) by substitution at 37
138	143		the 3-position to any extent; or (iii) by substitution at the nitrogen atom 38
139	144		with alkyl, dialkyl, benzyl, cycloalkyl, or methoxybenzyl groups or by 39
140	145		inclusion of the nitrogen atom in a cyclic structure. For the purpose of 40
141	146		this paragraph, the term "isomer" includes the optical, positional, or 41
142	147		geometric isomer." 42
143	148		SECTION 1.(f) G.S. 90-89(7) reads as rewritten: 43
144	149		"(7) Synthetic cannabinoids. – Any quantity of any synthetic chemical compound 44
145	150		that (i) is a cannabinoid receptor agonist and mimics the pharmacological 45
146	151		effect of naturally occurring substances or (ii) has a stimulant, depressant, or 46
147	152		hallucinogenic effect on the central nervous system that is not listed as a 47
148	153		controlled substance in Schedules I through V, and is not an FDA-approved 48
149	154		drug. Synthetic cannabinoids include, but are not limited to, the substances 49
150	155		listed in sub-subdivisions a. through p. r. of this subdivision and any substance 50
151	156		that contains any quantity of their salts, isomers (whether optical, positional, 51 General Assembly Of North Carolina Session 2025
152		-	Page 4 ~~Senate Bill 450-First Edition~~
	157	+	Page 4 DRS15191-NI-1A
153	158		or geometric), homologues, and salts of isomers and homologues, unless 1
154	159		specifically excepted, whenever the existence of these salts, isomers, 2
155	160		homologues, and salts of isomers and homologues is possible within the 3
156	161		specific chemical designation. The following substances are examples of 4
157	162		synthetic cannabinoids and are not intended to be inclusive of the substances 5
158	163		included in this Schedule: 6
159	164		… 7
160	165		n. Indazole carboxaldehydes. Any compound structurally derived from 8
161	166		1H-indazole-3-carboxaldehyde or 1H-indazole-2-carboxaldehyde 9
162	167		substituted in both of the following ways: 10
163	168		… 11
164	169		2. At the carbon of the carboxaldehyde by a phenyl, benzyl, 12
165	170		naphthyl, adamantyl, cyclopropyl, or propionaldehyde group; 13
166	171		whether or not the compound is further modified to any extent 14
167	172		in the following ways: (i) substitution to the indazole ring to 15
168	173		any extent, (ii) substitution to the phenyl, benzyl, naphthyl, 16
169	174		adamantyl, cyclopropyl, or propionaldehyde group to any 17
170	175		extent, (iii) a nitrogen heterocyclic analog of the indazole ring, 18
171	176		or (iv) a nitrogen heterocyclic analog of the phenyl, benzyl, 19
172	177		naphthyl, adamantyl, or cyclopropyl ring. 20
173	178		o. Indazole carboxamides. Any compound structurally derived from 21
174	179		1H-indazole-3-carboxamide or 1H -indazole-2-carboxamide 22
175	180		substituted in both of the following ways: 23
176	181		… 24
177	182		2. At the nitrogen of the carboxamide by a phenyl, benzyl, 25
178	183		naphthyl, adamantyl, cyclopropyl, or propionaldehyde group; 26
179	184		whether or not the compound is further modified to any extent 27
180	185		in the following ways: (i) substitution to the indazole ring to 28
181	186		any extent, (ii) substitution to the phenyl, benzyl, naphthyl, 29
182	187		adamantyl, cyclopropyl, or propionaldehyde group to any 30
183	188		extent, (iii) a nitrogen heterocyclic analog of the indazole ring, 31
184	189		or (iv) a nitrogen heterocyclic analog of the phenyl, benzyl, 32
185	190		naphthyl, adamantyl, or cyclopropyl ring. Substances in this 33
186	191		class include, but are not limited to: AKB-48, fluoro-AKB-48, 34
187	192		APINCACA, AB-PINACA, AB -FUBINACA, 35
188	193		ADB-FUBINACA, and ADB-PINACA. 36
189	194		…." 37
190	195		SECTION 1.(g) G.S. 90-90(2)h1. reads as rewritten: 38
191	196		"h1. Fentanyl immediate precursor chemical, 39
192	197		4-anilino-N-phenethyl-4-piperidine 40
193	198		(ANPP).4-anilino-N-phenethylpiperdine (ANPP)." 41
194	199		SECTION 1.(h) G.S. 90-91(k)11. reads as rewritten: 42
195	200		"11. Dehydrochlormethyltestosterone,Dehydrochloromethyltestosterone," 43
196	201		SECTION 1.(i) G.S. 90-91(k)16. reads as rewritten: 44
197	202		"16. Mesterolene,Mesterolone," 45
198	203		SECTION 2. This act is effective August 1, 2025, and applies to offenses committed 46
199	204		on or after that date. 47